💊 Drug Interaction Checker
Psilocybin can interact dangerously with certain medications, especially those affecting serotonin. Use this
tool to check for known interactions.
Disclaimer: This is not medical advice. Consult your doctor.
Common Interactions
Lithium (Mood Stabilizer)
Effect: Can cause seizures and heart problems. Even low doses of psychedelics combined with Lithium can be fatal or cause a fugue state.
Recommendation: strictly AVOID.
Tramadol (Painkiller)
Effect: Lowers seizure threshold. Combined with psychedelics, it significantly increases the risk of seizures and Serotonin Syndrome.
Recommendation: strictly AVOID.
SSRIs (Prozac, Zoloft, Lexapro)
Effect: SSRIs downregulate serotonin receptors. This often "blunts" or completely nullifies the effects of mushrooms.
Recommendation: Not physically dangerous (usually), but often leads to a disappointing experience. Do not stop meds without doctor supervision.
Benzodiazepines (Xanax, Valium)
Effect: "Trip Killers." They reduce anxiety and the intensity of the trip.
Recommendation: Safe to use to end a bad trip, but will reduce the psychedelic effects.