Research Institutions
These academic and research centres are conducting or have conducted rigorous clinical and scientific investigation into psilocybin and related compounds.
MAPS β Multidisciplinary Association for Psychedelic Studies
Focus: Clinical research into MDMA and psychedelic-assisted therapies; policy reform; therapist training
MAPS was founded in 1986 by Rick Doblin, Ph.D., with the mission of developing legal contexts for people to benefit from carefully used psychedelics and marijuana. It is a non-profit research and educational organisation based in the United States. MAPS has been instrumental in sponsoring the FDA-approved Phase 3 clinical trials of MDMA-assisted therapy for PTSD, and has also funded earlier-phase research into psilocybin, LSD, and other compounds.
Psilocybin research: MAPS has supported pilot studies exploring psilocybin for anxiety related to life-threatening illness and for other conditions. Their work contributed to psilocybin receiving FDA Breakthrough Therapy designation in 2018 for treatment-resistant depression and again in 2019 for major depressive disorder.
Therapist training: Through the MAPS Public Benefit Corporation (MAPS PBC), MAPS has developed comprehensive training programmes for therapists in psychedelic-assisted therapy, with curricula that cover both MDMA and psilocybin modalities.
Policy advocacy: MAPS advocates for research-based drug policy and has submitted comments to regulatory bodies in the US, Europe, and internationally. Their work has contributed to regulatory attention on psychedelic-assisted therapies in Australia, Canada, and the UK.
How to get involved: MAPS accepts donations and has volunteer opportunities. Researchers can explore collaboration through their open science initiatives. Participants can search ClinicalTrials.gov for current MAPS-sponsored trials.
Website: maps.org
Johns Hopkins Center for Psychedelic and Consciousness Research
Focus: Rigorous clinical trials; therapeutic applications; neuroscience
The Johns Hopkins Center for Psychedelic and Consciousness Research, launched in 2019, is one of the world's leading academic centres for psychedelic science. Led by Matthew W. Johnson, Ph.D., and Roland Griffiths, Ph.D. (until his death in 2023), the centre has published landmark studies on psilocybin for depression, smoking cessation, alcohol use disorder, Alzheimer's disease, anorexia nervosa, and more.
Landmark publications: The 2006 Griffiths et al. study in Psychopharmacology demonstrated that psilocybin can occasion mystical-type experiences of substantial personal meaning and spiritual significance. Subsequent studies in 2011 and 2016 confirmed lasting positive personality changes and therapeutic potential. A 2020 JAMA Psychiatry paper showed rapid and large reductions in major depressive disorder with two psilocybin sessions.
Current trials: The centre is running multiple trials, including studies of psilocybin for Alzheimer's-related depression, eating disorders, and long-term follow-up of earlier cohorts. See their website for current recruitment information.
How to participate: Research participants can apply through the Johns Hopkins website; eligibility criteria vary by study. The centre also offers training for clinicians and researchers through courses and workshops.
Website: hopkinspsychedelic.org
Imperial College Centre for Psychedelic Research
Focus: Neuroscience, mechanisms of action, clinical trials in the UK
The Imperial College Centre for Psychedelic Research, established in 2019 and led by Professor Robin Carhart-Harris and subsequently by Dr David Erritzoe, is Europe's leading academic centre for psychedelic neuroscience. The centre has made foundational contributions to understanding how psilocybin works in the brain, including the discovery of the "entropic brain" hypothesis, the role of the default mode network, and the neuroplasticity effects of psychedelics.
Key research: Imperial's 2021 trial published in the New England Journal of Medicine compared psilocybin therapy to escitalopram (an SSRI) in patients with treatment-resistant depression β a landmark study demonstrating psilocybin's effectiveness relative to established pharmacotherapy. Their neuroimaging work using fMRI has illuminated the brain mechanisms underlying psychedelic experiences.
Training and education: Imperial offers MSc and PhD opportunities in psychedelic research. The centre also engages in public science communication to promote evidence-based understanding of psychedelics.
Website: imperial.ac.uk/psychedelic-research-centre
NYU Langone Center for Psychedelic Medicine
Focus: Addiction, palliative care, depression, therapist training
The NYU Langone Center for Psychedelic Medicine conducts clinical research at the intersection of psychedelic science and medical care. The centre is particularly known for its pioneering work on psilocybin-assisted therapy for alcohol use disorder (published in JAMA Psychiatry, 2022) and for end-of-life anxiety in cancer patients.
Alcohol use disorder research: A 2022 randomised controlled trial by Bogenschutz et al. found that two psilocybin sessions significantly reduced heavy drinking days in people with alcohol use disorder compared to a diphenhydramine control. The difference was clinically meaningful and maintained at eight months.
Palliative care: Earlier NYU research demonstrated that psilocybin significantly reduced existential anxiety, depression, and demoralisation in cancer patients facing life-threatening diagnoses, with effects lasting at least six months after a single session.
Clinical training: NYU offers training programmes for mental health professionals in psychedelic-assisted therapy through its Bluestone Centre initiatives.
Website: med.nyu.edu/centers-programs/psychedelic-medicine
Usona Institute
Focus: Psilocybin synthesis, supply for trials, non-profit research model
Usona Institute is a Wisconsin-based non-profit medical research organisation with a mission to conduct and support pre-clinical and clinical research to develop psilocybin and other consciousness-expanding medicines as therapeutics for mental health. Unlike for-profit pharmaceutical companies, Usona's non-profit status means any psilocybin therapies it develops will be aimed at broad, affordable access.
PSIL201 trial: Usona sponsors the PSIL201 trial β a Phase 2 randomised controlled trial comparing psilocybin to niacin (a placebo) for major depressive disorder. Results have been encouraging, supporting FDA Breakthrough Therapy Designation.
Compound supply: Usona operates a GMP (Good Manufacturing Practice) psilocybin synthesis programme to supply research-grade psilocybin to approved trial sites, addressing a significant bottleneck in psychedelic research.
Website: usonainstitute.org
Beckley Foundation
Focus: Policy reform, scientific research collaborations, international advocacy
Founded in 1998 by Amanda Feilding, the Beckley Foundation is a UK-based think tank and research organisation that has been at the forefront of psychedelic science and drug policy reform for over two decades. Feilding has personally championed rigorous scientific investigation of LSD and psilocybin at a time when such research faced significant institutional resistance.
Research collaborations: Beckley has collaborated with Imperial College London on landmark LSD neuroimaging studies and psilocybin research. The Beckley/Imperial Research Programme produced some of the first neuroimaging data showing how psychedelics alter brain connectivity.
Policy work: Beckley publishes policy briefings, engages with UN drug control bodies, and advocates for a regulated, health-centred approach to drug policy. They have contributed to policy discussions in the UK, US, and internationally.
Website: beckleyfoundation.org