⚖️ Tolerance Calculator
Calculate your psilocybin tolerance and optimal dosing schedule
📊 Your Usage Information
📈 Results
Enter your information and click "Calculate Tolerance" to see results
📚 Understanding Psilocybin Tolerance
How Tolerance Works
Psilocybin tolerance develops rapidly—within hours of ingestion—and follows a predictable pattern:
- Immediate (0-12 hours): Tolerance peaks at nearly 100% - taking more psilocybin has minimal additional effect
- Day 1-3: Tolerance remains very high (50-80%), requiring 2-3x normal dose for same effects
- Day 4-7: Tolerance gradually decreases (20-50%)
- Day 8-14: Tolerance nearly gone (0-20%), baseline response restored
Cross-Tolerance
Psilocybin shows cross-tolerance with other serotonergic psychedelics:
- LSD: Full cross-tolerance - using one affects tolerance to the other
- Mescaline: Significant cross-tolerance
- DMT: Partial cross-tolerance (less pronounced)
- MDMA: Different mechanism - minimal cross-tolerance
Microdosing Tolerance Management
- Fadiman Protocol (every 3rd day): Minimizes tolerance buildup, most sustainable long-term
- Every Other Day: Some tolerance accumulation, may need breaks every 6-8 weeks
- Daily: Not recommended - rapid tolerance requires increasing doses, unsustainable
⚠️ Important Notes
This calculator provides estimates based on typical tolerance patterns. Individual variation exists due to metabolism, body chemistry, and other factors. Always start with lower doses when uncertain. Taking larger doses to overcome tolerance is not recommended.