🔬 Stacking Compatibility Checker
Check interactions between supplements, nootropics, and medications with psilocybin
Select Substances to Check
🍄 Psilocybin
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Detailed Interaction Analysis
⚠️ Disclaimer: This tool is for educational purposes only and should not replace professional medical advice. Always consult with a healthcare provider before combining any substances, especially if you are taking prescription medications.
Popular Stacking Combinations
Stamets Stack
Psilocybin
Lion's Mane
Niacin
Classic neurogenesis stack developed by Paul Stamets for cognitive enhancement and neural repair.
Cognitive Enhancement
Psilocybin
Lion's Mane
Bacopa
L-Theanine
Comprehensive nootropic stack for focus, memory, and learning.
Mood Support
Psilocybin
Omega-3
Vitamin D
Magnesium
Foundational supplements that support mood regulation alongside microdosing.
Energy & Focus
Psilocybin
Cordyceps
B-Complex
CoQ10
Stack for sustained energy and mental clarity without stimulants.
📚 Quick Reference Database
Common substances and their general compatibility with psilocybin microdosing:
| Substance | Category | Compatibility | Notes |
|---|---|---|---|
| Lion's Mane | Functional Mushroom | Synergistic | Enhances neurogenesis; core Stamets Stack component |
| Niacin (B3) | Vitamin | Synergistic | May enhance distribution; causes temporary flush |
| L-Theanine | Amino Acid | Compatible | Promotes calm focus; reduces any anxiety |
| Caffeine | Stimulant | Caution | May increase anxiety; reduce dose or avoid |
| CBD | Cannabinoid | Compatible | May reduce anxiety; generally well-tolerated |
| THC/Cannabis | Cannabinoid | Caution | Can intensify or alter effects unpredictably |
| SSRIs | Antidepressant | Avoid | Serotonin syndrome risk; reduces effectiveness |
| MAOIs | Antidepressant | Dangerous | Severely dangerous; can potentiate 10x+ |
| Lithium | Mood Stabilizer | Dangerous | Risk of seizures; absolutely contraindicated |
| Omega-3 | Fatty Acid | Synergistic | Supports brain health; recommended baseline |
| Magnesium | Mineral | Compatible | Reduces anxiety and muscle tension |
| Vitamin D | Vitamin | Compatible | Supports mood; often deficient |
| Ashwagandha | Adaptogen | Compatible | Stress reduction; well-tolerated |
| Rhodiola | Adaptogen | Compatible | Energy and focus; mild MAO effect at high doses |
| Cordyceps | Functional Mushroom | Synergistic | Energy and stamina; complementary benefits |
| Reishi | Functional Mushroom | Compatible | Immune support and calming; evening use |
| Alcohol | Depressant | Caution | May reduce benefits; occasional light use OK |
| Benzodiazepines | Sedative | Caution | May reduce effects; discuss with doctor |